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Cathelicidin and innate immunity

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The early randomized study enrolled 34 people and investigated topical LL37 for venous leg ulcers over a four-week treatment period.

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Record 01

Treatment with LL-37 is safe and effective in enhancing healing of hard-to-heal venous leg ulcers: a randomized, placebo-controlled clinical trial. ↗

Record 02

Evaluation of LL-37 in healing of hard-to-heal venous leg ulcers: A multicentric prospective randomized placebo-controlled clinical trial. ↗

Record 03

Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks ↗

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The early randomized study enrolled 34 people and investigated topical LL37 for venous leg ulcers over a four-week treatment period.

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Some lower-concentration groups improved healing predictors; the highest-concentration group did not differ from placebo.

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HEAL LL-37 randomized149 participants;148 were treated and144 entered the full efficacy-analysis set. It compared topical LL-37 plus compression with placebo plus compression.

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The phaseIIb full-cohort analysis did not find a significant healing improvement with LL37.

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